I decided to install arch once. Didn't have any issues per se, but spent far too much time going through all the window manager options, file browser options etc etc etc.
I eventually decided that I needed an os to do stuff, not be the stuff to do.
That (and the at the time, in my personal opinion, superior to anything else Office 2010 with the improved tabbed interface) was the reason I went back to Windows. Nowadays most of the time I don't even bother to change the color scheme an set a background image.
I just recently started to customise my Powershell profile. Let's see where this leads...
I think it depends on whether you can do stuff in the os even if it is not yet set up exactly perfectly. If so, then you can do stuff when you need to, and play with the os when you want to.
But obviously some will be too distracted from doing anything such that that's still a bad idea.