I couldn't find a preview for the 2nd edition, but the 1st edition seemed quite out of date?
The frontend work I tend to be dealing with at this point in my career usually involve proper web "apps" (dashboards, visualizations, editors, etc) rather than the web "pages" that the DOM was well suited for. The main difference is the need for client-side state and realtime interactivity that doesn't need a full backend rerender every time. Yes you can write all that in plain JS but at some level of complexity you'd just be reinventing your own framework.
What I'd like to see isn't so much getting rid of all the frameworks in favor of vanillajs (unless ecma improves it dramatically), but a good guide on how to integrate the various pieces of modern frameworks in a neat and maintainable way. I'm not sure that it's really doable right now given the pace of change and how quickly everything becomes obsolete. Clean Code has some interesting ideas but isn't exactly a drop in fit to the JS ecosystem.
Anyway, just thinking out loud...
