Possibly, but there's still huge technological hurdles. Sure, if we could figure out how to make everyone biologically immortal, then a 100,000 year journey wouldn't necessarily require a generation ship, but it does make me wonder how viable it would be socially (would society inside the ship break down and result in the crew destroying themselves somehow). Also, even without worrying about aging, how do you create a completely self-sustaining biosphere for these immortal humans to live in for eons? Building an FTL drive seems, in a way, to be simpler than this. Also, how do you deal with things like asteroid collisions over such a huge distance, at the speeds likely to be gained?

Most sci-fi just doesn't think of this stuff because the idea of a ship traveling for 100s of thousands, or even millions of years, is almost too much to consider for us. Making a ship that takes a few months or years to get somewhere is much easier for us to think about, because we've done such things before, so sci-fi always either invents FTL drive, or just conveniently ignores it and hopes the audience is too ignorant of the vast distances between stars to notice (which they usually are).