That's part of the sadness. But it is possible to spread throughout the solar system, and so it's a matter of scale after that.
At one time, nobody could leave the shoreline or they'd be lost forever. We have invented our way out of most of it.
Now, I enjoy thinking about how _different_ it would be from any journey we've taken. Something more like frozen embryos and robotic caregivers than a ship full of brave men. I mean, what would they eat? But it is not at all impossible, just unfathomable to us.