Not all single points of failure are made equal, and password reuse is a much bigger problem than the possibility of your password manager getting hacked, assuming you choose a good one.
All that seems a lot more risk and hassle than choosing 2 or 3 good passwords (correct horse etc), then making variants that you can remember for each site.
99.9% of people are going to be unable to remember a reasonable number of variants that aren't trivially deterministic and once things are very similar to another its increasingly easy to confuse them.
You can sync your encrypted password vault between local devices and a remote resource which has access to the vault but not the key for same. At that point is very very hard to get pwned or lose access to anything. This was a solved problem 20 years ago.
