But then you're moving towards less of an app with configuration, and more of a "Here's a new programming language and frameworks to write your own app!" Situation.
If possible I'd rather examine why people need so many config options, and design from the start so that things don't need to be manually configured as much.
If a turning complete config really is the way to go, I'd rather just use JS or Python, not something metaprogramming focused that just invites and almost requires building more layers on top to do real programming.