"This is an important, though uncommonly discussed, issue in the translation of evidence from cancer screening trials.1 It is known that overdiagnosis (treatment of cancers that would have been no threat), and high false positive rates (misdiagnosis) lead to medical harms and unnecessary surgeries, chemotherapy, and radiation...
...margin of benefit suggested by the analysis above it seems likely that if there is a benefit to screening mammography it is balanced out by mortal harms from overdiagnosis and false-positives"
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