Chakras are real so as Kundalini [0]. However, these aren't physical in nature, rather, they are on subtle body of consciousness. Now, that's not possible to prove scientifically yet, but with your dedicated regular practice, you can experience them yourself as this guy on HN did [1] which inspired me to start my own exploration (back in 2014) and have intense experiences which remains with me.

0: https://www.amazon.in/Kundalini-untold-story-Om-Swami/dp/818... 1: https://news.ycombinator.com/item?id=6910041