I see people occasionally mention shortcuts or vim as reasons they can't switch layouts, but I've done it multiple times and you just learn the new spots, same as typing words with all the letters that moved. It never felt like a showstopper for me.
Alas, it's not only about learning new spots. I never use any of the super useful motions with [ and { in Vi simply because they're only accessible via AltGr in my national layout.