If you look at alternative layouts in a vacuum and you base it on things like word frequency or character frequency, I'm certain you're right, but outside of the bubble and when you're interacting with software that all assumes that you're using qwerty and organizes its own keyboard interactions with that assumption, the advantages become much less clear.

In fact, trying to account for that is why colemak uses the zxcv keys where they are, if I'm not mistaken.

So I don't really agree with the notion that you get a huge benefit at all. You are potentially getting some ergonomic benefit in certain contexts (like typing out essays) while at the same time sacrificing ergonomics of keyboard shortcuts you may or may not be able to change and the mental overhead required to remap your muscle memory to fit it.

These tradeoffs are remarkably apparent to me as someone that uses a Kinesis board (and have used a variety of small, bespoke keyboards). There's a lot of tasks that simply aren't suitable for this keyboard, even if I remap the keys with QMK to try to better suit that context. If you need a key to be immediately accessible, having it placed inside a layer just isn't good enough.

With that being said, I'd encourage people to try these things out and see for themselves. I personally don't think they're all that useful, but there's dozens of others that I'm sure swear that using dvorak or workman or colemak or whatever alternative layout changed their life. Just don't expect miracles.