"Psilocybin treatment led to a dose-dependent decrease in cell cycle arrest markers (p21, p16, and p53) and an increase in markers of DNA replication (phosphorylated-Retinoblastoma protein; pRB) and proliferation (PCNA), as compared to vehicle-treated cells". They don't say it IS carcinogenic. At least this statement favors taking psilocybin after fasting/senolytics/autophagy induction.
"may mediate SIRT1-dependent pathways which impact cellular senescence". So if senescence is delayed by it and during this period SIRTs are activated, it may be anti-cancerous.
> Some of the largest clinical trials, in fact, had to be aborted because the patients receiving antioxidants had a higher incidence of cancer than patients who did not receive them.
https://www.cancer.gov/news-events/cancer-currents-blog/2015...
Preventing cellular senescence sounds like the same kind of thing, messing with an existing mechanism put in place to prevent cancer.
There are a ~dozen of studies on dasatinib (anti-cancer drug) + quercetin (senolytic) for curing osteoarthritis in humans, improving heart tissue etc, with dasatinib used as a senolytic. Navitoclax (anti-cancer drug) also used as senolytic in some studies.
In this context it seems that adverse effects from senolytics may be more pronounced in cancer-prone, in younger age or if taking them continuously (not like 5 days per month or so letting some senescent cells to emerge). Yet Sinclair's new venture TallyHealth, for example, are selling a 5 in one capsule, containing apart from other stuff 500 mg quercetin and 100 mg fisetin (senolytics) with an expectation of daily intake. And his 80y old dad is taking senolytics daily with still no cancer.
