I think the real solution is to manually convert component datasheets to spice models (I think there are already commercial databases of these), simulate the circuit, and then get a language model like GPT-4 propose changes to the circuit to make it perform better.

The real question becomes how to interface the spice model and the language model - do you for example let it connect a virtual oscilloscope to any node, and give the language model the results back as plain numbers?