No, but the idea of a totality of physics is: that there's nothing outside it that we don't understand. That's very anthropocentric. And heard in the dismissals people give of possibilities or observations that "violate a law of physics".

There are some pretty weird stuff out there outside the average UAP cannon — of metallic orbs, cigars and clamshells — that may qualify as your intrusions; good word!

Science lives at the edge of the unknown. In this era I think we need to engage in far-out speculation if we're going to understand what comes — especially if we hope to understand it from a non-anthropocentric point of view! Ha ha ha! :)