This is now the second time AMD has screwed up the C6 state. Ryzen first gen would hang daily for me when due to a similar bug.
A motherboard update from MSI applied something from AMD and that fixed the issue.
I guess fighting tooth and nail to disable any and all of these sleep states from the get go is worth it...
As a systems seller you get most of the markup but also most of the responsibility, so handwaving 'sorry AMD fucked up' won't do it. You know have an installed base that might crash every 1024 days, which for unattended systems is long but not that long. Worse if you have hardware redundancy, there's still a chance they all booted around the same time so will crash around the same time.
Customers will be proactive and follow the intelligent periodic reboot schedule you propose for a time (see the 787 overflow bugs stories), while asking for a fix. The fix needs to still be OK with all the specs you sold. If one of these specs depends on sleep states, you'll have to find a solution around it and deploy it fleetwide. If a microcode update fixes it, yay. If the problem can't be winked away with a software patch, now the blast radius is bigger and you're still supposed to do as much as possible to use the least energy possible in most idle states...