Yes, but it won't happen, as states, cities, and feds are suing pharmaceutical companies, even pharmacies like Walgreens into oblivion. (Walgreens paying $290M to the city of San Francisco after a recent lawsuit.) And doctors don't want to be in that practice of prescribing opioids. In other words, even if all synthetics are legalized, there won't be any doctors to prescribe them, there won't be any pharmacies who want to sell them. That's why people flock to the underground market to get synthetics, even if you legalize all drugs in the states.