For Americans, this concept seems to be almost alien given the (at least from an European POV) more or less constant gridlock between House, Senate, Presidency and whatever the 50 states make out of that regarding enforcement.

Or, to put it differently, they prefer the Wild West and barely self-regulated markets because they have completely lost any trust in government to create and modernize laws - a viewpoint that does make sense given the ridiculous age of key players in Congress. Feinstein is 90 years old, both likely Presidential candidates are over 75, Senators' median age is 65. How can anyone expect these people to even understand modern issues?!

I think this is also the cause why so many American companies failed or have massive difficulties entering the European market. They simply cannot think that other countries have governments that actually govern and regulatory agencies that don't take it well if foreign companies try to buy their way out of trouble.

On the surface level you are right.

But look at the cost of medicine development, it has exponentially risen to billions in the last decades, stifling innovation. And although it maybe got a bit safer, it didn't get exponentially safer.