I wonder which full-stack JS framework you used that you thought made life harder? One of the things that gets me mad is the idea of putting it all in one single box, as React is indeed very (needlessly) complex and so can be other libraries, but that doesn't mean the paradigm of JavaScript front-to-back is fundamentally flawed.
edit: Something else I should've added to my comment is that the HTMX approach is terrible if you ever need more than just the web-client (i.e. a mobile app, native or otherwise) since you will now have to implement an API anyway, which you could've done in the first place by taking the usual approach to development.