Would you say not having ortholinear keys is a big difference for ergonomics?I don't think there is much proof in terms of scientific studies that column stagger is better (column stagger is usually preferable over ortholinear), so can only really give my personal experience. I strongly prefer column stagger, I can still type row stagger and sometimes use my laptop's keyboard when I travel, but all these lateral movements feel awkward now.
I've also been eyeing the Kinesis Advantage 360
The 360 is really nice (I have a 360 Pro), but I'd order it somewhere where you can return it easily (eg. Kinesis themselves). For me, the Gateron Browns in the 360 are quite a large regression compared to the Cherry Browns in the Advantage2. The Gaterons are smoother, but their actuation point is way lower. Gateron specs say 2mm, but it's closer to 3mm in practice. This makes typing on the 360 quite tiring for me. So it's mostly collecting dust currently (I am using the Advantage2 and the Model 100 most of the time). But this is really personal, some other people do like the Gateron switches.
I wrote up a short review of the 360 Pro here:
https://danieldk.eu/Posts/2023-04-15-Advantage-360-Pro.html