The only thing you can't do is have both untyped and monolithic at the same time.
For example the Filesystem Browser (FSEdit) from 1980 was written in Flavors. It actually uses an explicit OOP system with hierarchical classes.
https://tumbleweed.nu/r/attic/sys78/file?name=lmfs/fsedit.li...
People use Python and JS, not Lisp.
Dynamic typing in Python and JS + medium-sized project = dumpster fire.
Dynamically typed microservices is where it is at.