I say this, because I was guilty of this exact shortcut thinking (in another comment). But I paused and thought to myself "I should run the numbers before just repeating the usual voltage drop criticism".
So I compared scenarios and it depends a lot on the topology, lengths, costs, and situation (new vs renovation).
Sure, a whole house system doesn't typically make sense, but I don't think that's what people are really talking about. I think people are interested in hybrid systems; e.g. DC power supply for each room.
I don't know if you meant it, but the sentence about "any sophomore level electrical engineering student can solve this" can easily come across as dismissive. I also think it gives too much credit to sophomore students. :)
I would have more confidence in an electrician apprentice on this one. I think they'd have more practical experience when it comes to figuring out what are the right questions to ask.
I did EE in college and do a fair bit of hands on residential electrical work.
P.S. How many sophomore level engineering students learn to do a sensitivity analysis?