My 3D printing needs are not seriously complicated, so I've found that OpenSCAD to be the best solution for me. Because I'm a programmer, a workflow focused on programmatically generating geometry is very intuitive. Everything else I've tried is too cluttered and complicated for what I want to do. It's weak when it comes to organic geometry, but most of what I make isn't organic-looking. If I needed to make something more organic, I'd probably make the base model in OpenSCAD first and then bring it into Zbrush.

I'm a noob but have learned Blender->3D-print. I can report that it works well enough for me.

WIP: https://www.therpf.com/forums/threads/scratch-built-space-tu...

Try solvespace. There is also the CAD sketcher addon for blender, but that's big software compared to solvespace.