story
In the horrifying event of a US-China war or similar they'd be front line units along with F-35s and other modern fighters, but as is they'll probably end up on service life extension and retired without ever being used much in combat.
The F-15 was sold to other nations and IIRC the majority of its air superiority engagements were with the Israeli air force.
The F-22 is foremost an air superiority fighter and was intended to replace all the air superiority F-15s (but not the F-15E Strike Eagles.) However the USAF didn't get enough F-22s so they still have air superiority F-15s and will for some years to come.