I would argue that the unipolar nature of Canada driven by the federal government's usurpation of provincial powers is causing us far more harm than any harm caused by provinces exercising their constitutional rights. What we have now is a weird system where almost all the power resides in Ontario and Quebec, with an extremely weird Faustian bargain of payoffs and bribes to Quebec (primarily financed by the other provinces) to keep them engaged in keeping the power center out east, concentrating a majority of the extractive parts of business (banking, head offices) and government there, which is causing major stagnation and loss of productivity in Canada. We need to get to a more multipolar setup so that when the east decides to do something insane it does much less damage over the time period they are pulling their heads out of their arses (this is basically what keeps America so strong but because they are already multipolar you can replace "the east" with New Yorkers, Californians, Illinoisians, Floridians, etc) and our constitution should have set us up for being exactly this. What happened instead is the federal government manufactured a bunch of rights they don't have and made us all worse off.