I'm honestly still trying to figure out what I want to do with it. I got the compact flash to use with a XT-CF-Lite v4. I'm still trying to figure out what DOS I'd like to use. I can get the OEM MSDOS 3.22 installed onto the drive, but that version's max partition size is 32MB, which isn't ideal when the compact flash is 4GB. FreeDOS supports that size and pre-386, but it was a pain to get it on there and is a bit overkill for a computer this old. Right now I'm considering a later MSDOS, but haven't decided on which one.
As far as software goes I'm waiting on finalizing the DOS before exploring games and development, but it was fun was to be able to run this port of Wolfenstein 3D:
https://github.com/jhhoward/WolfensteinCGA
Besides all that I'm thinking of maxing out the RAM (it's 640k now, but can take an additional 128k for video), and maybe adding a real time clock and network card. I do have another Tandy 1000 TX, so I could see how 80's networking worked. That is probably another can of worms though.