Given the fact you’ve presumed I’m not able to make factual assertions about geographically bounded regions, I’m not going to give the effort to seriously read the rest of your reply.
Northern Ohio is not Appalachia, outside of one eastern most county.
Southern-Eastern Ohio mostly is.
Oh, yeah - if you’re right over the river, 20 years of my life is right next to you & I’ve had many a trip to the Parkersburg mall in my youth :)
Perhaps you know the route towards your river crossing I had to take that is a few strung out miles of completely crumbling mobile homes & the smell of natural gas/sulfur that stings your nostrils when rolling down your car windows.
IIRC there is even a small, many decades rusted over & tree vined carnival/amusement park type thing with a little rollercoaster that you pass on the way to the toll bridge. Can only imagine that was some day a fun place, now it stinks of gas & sulfur runoff.
Thankfully I was lucky enough to not grow up in that exact zone. Cannot imagine the cognitive deficits a childhood of breathing that in causes.