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What did diabetics do before treatment and therapies? People with asthma, myopia, or really any other health issue? What does it matter?
> Do we know that the treatments help in the sense that treated people commit suicide less than untreated people before the treatments were available?
Why do we need to know that? What's the point of it? We don't evaluate effectiveness of any treatment by comparing current data with likely non-existent, pre-treatment (read: more than a century old, in this case) data.