I am building one now as a single founder, with plans to never grow beyond a few people, and I'm using Clojure + Postgres (having done Python for almost 20 years!). I do technical due diligence for private equity companies for a living, and I evaluated two Clojure companies. It was amazing how much they could avoid in terms of problems as a small team by leveraging the JVMs concurrency and threading capabilities. No worrying about microservices, managing crazy k8 systems, or complex CQRS problems, no outgrowing pokey ORMs (a problem I have talked to way too many mid stage companies about who started on Rails or Django - huge elephant in the room there). I intend to use a mix of HTMX, some Reframe (a clojurescript reactive framework over react) and webassembly on the front end.

Clojure's not the easiest thing to get into, the stability and documentation and libraries are great.