Another example of the subversion that reinforces this "truth = negativity" moral:
(Spoilers)
The episode where they're trapped in the house with shapeshifting memory-modifying aliens pretending to be loved family members. Traditionally you would expect such a problem to be resolved through the power of love, or some other positive quality that bonds the family in a way the aliens can't fake. Rick and Morty inverts it and the problem is solved through the power of resentment. The message is clear - reality is ugly and messy and painful, and "love" is a powerful illusion created to fill a biological purpose, and you should be suspicious of it if you want to act rationally, which you should. Admittedly, the Mr Poopybutthole denouement partially redeems the episode by subverting its own point and cautioning against taking it too far, but the same message crops up too often in Rick and Morty to be ignored.