Manual mining produces good rewards in nugget rich grounds with dense primary rewards, if you move (say) 10,000 tonnes of material you find a lot of gold, even without extra processing (such as gold cyanidation).
When you hit low grade regions there simply isn't as much gold present - not only do you still need to move 10,000 tonnes of material, you know also need to chemically bind and extract in order to get less gold overall.
The pattern is, the easy is cheap (in terms of effort), the harder stuff costs more (in terms of effort), and minor advances in technique aside .. everything ladders upwards to cost more in extraction effort for less return.
It's been true for gold, for copper, for fossil fuels, etc.
Historically you can see hard data for this in something like [1] which is sadly a subscription service.
[1] https://www.spglobal.com/marketintelligence/en/campaigns/met...