Hate to break it to you … but the “industry” that is the “anime industry” has been quietly adopting the latest technology for years. There are notable exceptions like Ghibli but for the most part, Japanese animation studios have been pioneering the state of the art in cell shading, lighting and post processing, adjustable “cartoon physics” style automated physics tweening and basically everything else in 3d computer graphics that will allow them to make the most of their artistic efforts. They’ve still got a vibrant story boarding process helped by the obvious intersection of anime with the vibrant drawing culture that produces the manga so many are based on… but beyond the storyboards they have been relentlessly trying to eliminate the need to tediously draw anything unnecessarily. There are entire 2D (not 3d!) animation tools that serve the professional 2D “cartoon” market that have widespread adoption. The 3d market is no different, the first cell shaded graphics code I read was all written with Japanese comments… “anime studios” (except Ghibli) don’t “prefer handcrafting every single frame” they use whatever tools are available and usable by them, that are capable of executing the artistic vision of the art director of that project/show/movie.
They care about the outcome not the process. They care that it looks how they want it to look, that it conveys what they want it to convey. This is artistic pragmatism at its finest. They will composite hand drawn graphics/animation, 2D computer graphics/animation, and 3D computer graphics/animation… it’s the final results that matter. I absolutely expect that once the tooling gets better at frame-to-frame consistency, once it is good enough AI/ML based animation tools will be widely adopted by the “anime industry” and it will be praised because it will do things like let small manga creators produce short OVA or movies or YouTube style content directly whenever they want without having to spend ages working with an animation studio and the fans will love it because they love the content and for the most part that love is not dependent on how the content was made.