There are too many questions to make any absolute statements. You hint at a couple here.
Specialization of requests reduces data transport, but increases testing surface area and drastically reduces caching options - including within the database. Years ago we discovered that our bottleneck in Oracle was being caused by query cache evictions (worse, in 9i only queries currently in the cache could run, so new queries were blocking in the query planner. I'm not sure if this was ever fixed.)
One of the important uses of etags within your infrastructure is to allow you to incorporate data manipulation into your caches. If your functions are deterministic you can store the results of a calculation, instead of the source data for that calculation. Cache hits then don't just save bandwidth, they also save computation, which reduces the sequential parts of the response, fighting Amdahl's Law.