I haven't yet, but my daily-driver-blocking issues during my last attempt were more around stability. Much of it I think is the hardware (OpenBSD and Haiku both would spontaneously reboot on occasion; given that it was more frequent on battery, I suspect it's some quirk with the Framework's power management - or maybe there's something in the iwx driver that freaks out the whole machine), and some were likely attributable to being on nightly; I'll have to re-test with beta4 (and maybe the latest UEFI updates on my machine) to see if that straightens some things out.
The lack of a built-in solution for full-disk encryption is also a blocker for me. It's something I keep meaning to try and tackle (say, by porting over OpenBSD's FDE implementation), but I ain't quite comfortable enough yet with Haiku's codebase to even know where to start.