I don't think most of the people taking, say, a class on Nabokov will complain much about needing Microsoft Word. In fact, I suspect the only inconvenienced person will be the lone EECS major using Linux (me :)).

As long as professors want hard copies, it won't be an issue. (Using MLA format with LaTeX is really, really easy.) However, some do expect digital copies for whatever reason. I've seen them ask for docs uploaded to the internal class website system, which is itself pretty horrible. I just hope I don't have to deal with it--even opening LibreOffice is more annoying than one could hope.