Having each fixture connection being a “home run” without any fittings between source and destination really reduces a lot of vulnerabilities. Having a central manifold that lets you easily turn off any tap is nice too.
A condo building I lived in did something wrong (I suspect) either a bad batch of PEX, or more likely, a batch that sat in the sun for a while, leading to multiple failures of hot water return lines in few years that were a mystery to pin down.
In my opinion, traditional trunk and branch plumbing is far more flexible and just as reliable. It also allows for a hot water recirculation loop, which is impossible with home-run plumbing.
Pex has zero UV resistance though, sp if exposed to sun at all it is the least durable.