1.) Performance. For example a run-time for a user-friendly little language that maps HTTP requests to SQL queries can be much faster than a language that does the same thing by plugging user-friendly APIs together. A custom run-time can parse an HTTP request string directly into SQLite op code while the JS developer is writing glue code that takes orders of magnitude more memory and CPU time.
2.) Static analysis. This means tools that are better at finding bugs, finding optimizations, visualizing structure, etc.