1. Generally, with large, complex systems like this, everything works, until it doesn't. All the big boys have major outages periodically. I just can't fathom how Twitter is going to handle the eventual certainty of a major outage when, as the author notes, in some cases there are teams that have 0 people left.
2. More than the technical issues, betting that Twitter will go bankrupt is the easiest bet one can make. Musk saddled Twitter with a shit ton of debt - even if things worked as they did before he had to cut tons of people due to the debt burden.
The issue I see is that #2 directly works against #1. Musk has said it will be lots of intense work adding new features to try to raise revenue. But making a ton of changes, probably with lots of shortcuts to get them out the door quickly, especially when so much institutional knowledge has walked out the door, will make keeping the site stable even that much harder.