I tried to open a 90GB file once (on a system with 16GB RAM), which it didn't like very much. It didn't actually crash, I just gave up on it before it completed loading the file (I suspect it may actually have worked eventually, utilising swap - but I imagine it would have been unusably slow). I think for such large files you really need an editor that doesn't buffer the entire file into RAM and loads chunks in from disk on demand.
That said, if your file is more reasonably sized (I've opened 7GB files no problem) then the performance and feature set you get is impressive. You can get instant scrolling to anywhere in the file, full syntax highlighting, find and replace, multiple cursors, etc all with reasonable performance. I find it does lag a little when making edits - especially with multiple cursors - but it's still quite usable.