Yeah, I put that to work a lot too, but nuke anything is great for sites you're probably not going to visit more than once since it doesn't clutter up your filter list just to get something out of your way (I'll even remove images or menus if they're distracting me from content while reading). If I do add a random one off website to uBO it's usually because they did something really obnoxious and I was like "Never again!"
It also supports a keyboard shortcut to enter the zapper picker mode, but depending on your browser you may need to enable shortcuts for the extension.