The trade off is that even legitimate mail that you are actively expecting (like an account confirmation or password reset mail) will be delayed by however long the sending server's retry interval is.

You also either need to apply the greylisting to some larger IP range (rspamd e.g. apparently uses /19 by default for IPv4) or otherwise specially handle some of the bigger mail providers, because some of them rotate through their servers between retries, so you could be in for a quite a long wait if you do per-individual-IP greylisting.

The biggest culprit I noticed this with was Amazon SES – a former mail provider of mine used per-individual-IP, non-configurable greylisting, and any mail sent through Amazon (which isn't just Amazon itself – quite a few companies are using Amazon SES for transactional mail and suchlike) would consequently almost always arrive several hours late (however randomly long it would take Amazon to finally re-use an IP during a subsequent retry attempt).

Even more infuriating, my mail provider's support would then claim that it wasn't their fault and they didn't know anything about any supposed greylisting.