Perhaps I was exaggerating a bit, but saying "I was doing 1.75 jobs" seemed to be in the same ballpark.
In this case, the startup was young, and (as is usually the case for startups) we had too much to do as it was. Also, coincidentally, we had a bunch of people having babies around the same time. There were simply not that many other people who could take on the work.
I think that's primarily the point I want to make: in a sizable corporation, probably a quarter of the company could disappear for a year or two and it wouldn't make any difference. A young startup just doesn't have that amount of spare capacity, so it's not realistic to think that going on extended leave (for whatever reason) won't have a large impact on the people that remain.
PS - if you want to argue that by "one quarter" should really be a third or 20% or 15% or whatever, knock yourself out. Point being that large corporations have a lot more redundancy that small startups, so the impact of someone leaving for an extended period is vastly different.