It won't tip the balance but it is a significant percentage of active users. I want to say greater than 15 percent but I can't remember where I saw that.
Anyway, it doesn't really matter what percentage of all users, just what percentage of techie word-of-mouth types use ad blockers. And that is a very significant percentage.
Maybe your mom can't change it herself but come Thanksgiving she's going to complain about it to you and you are going to fix it so she has an ad free experience again.