365 / 7 ≈ 52 (weeks) * 5 (work days per week) * 8 (hours per day) = 2080 hours per year
Given that very estimated number, vacation, holidays, and sick time all count as extra benefit.
One convenient aspect of this number is that if you go ahead and factor in 2 weeks of PTO/holidays/sick days, then the number of hours actually worked drops to 2000. That makes the mental math tremendously simple, albeit not 100% accurate: 100k salary / 2k ≈ 50 per hour