To really risk everything I have to burn bridges, damage my brain, and lose all my money.
In the end, you always have yourself. Except when you die. And then it doesn't matter.
Interestingly, though, I've always stopped for people on the side of the road to render aid and had many fun stories come from it but I almost never do when I have women in the car. I'm not entirely sure why but I don't.
The only exception was years ago on the Road to Hana where it was after dark on the South East side of the island and we came upon a family with a busted tyre. But I think on the mainland, probably not.
So maybe there's more to loss than oneself. I think I'd eat total death myself over harm to those I am responsible for.
You always have yourself but consider also how much impact in psyche it might have, will you really have "yourself" after blowing all the savings? It could trigger regret (especially if some opportunity shows up after savings are gone) and could spiral down into depression. It is easy to say "I am strong, I would handle it" before something bad happens.
I think the opportunity cost thing is a meaningful thing, but I doubt it'll really hurt since I have significant amounts of money I can draw on through my network.