Yeah, I use Home/End/PgUo/PgDn constantly, so much that having to use any modifier for it is just not acceptable to me. A secondary factor is that there are often keyboard shortcuts that combine Home/End/PgUp/PgDn with (combinations of) Shift/Ctrl/Alt, so having to add another modifier to those just makes it really inconvenient.

There is a sweet spot of the number of keys available for use without modifier keys, and that sweet spot may be different for everyone, but it is closer to 100 for me.