What his father is experiencing is luck mixed with good genetics. Plus, additional support of good diet and exercise. Yes, we all can control our diets and exercise. However, we cannot control the medication that we take, which carry side effects. We cannot control what is in our food, we cannot control the air we breath, we cannot control cancer and hundreds other diseases. There are so MANY other factors.
If his father grew up somewhere where lead is a problem, I have a feeling the outcome might have been different.
The whole article is useless. My grandfather was an awful person, smoked all his life, drank most of it, and ate whatever he could. Lived to 78 and was healthy, at that point he committed suicide as he could not live without his wife, which passed away few months earlier. Ironically he was an awful husband.
This is all anecdotal and useless.
All of this is about taking actions that reduce risk statistically. None of this is about a magic action that will prevent all disease.
>We cannot control what is in our food, we cannot control the air we breath, we cannot control cancer and hundreds other diseases.
Seriously? The answer to all of the above - Yes, we can!
I get that most people on HN, can control the air they breath as they have the means to decide where they want to live, this isn't the case for most of the people.
Cancer is literally just a numbers game, people in perfect health at their PEAK get diagnosed with cancer. A top club soccer player is now going through testicular cancer treatment.
I am not sure how general person can control any of this.
In the same vein, you don't really get a choice in most cancers. Sure, you can do things like never smoke tobacco, but you might just be an 8-year-old with bone cancer. And lots of other afflictions and diseases are similar in this manner, much like you probably won't be able to avoid whatever cold is circulating in your workplace.
And I've not seen any proof otherwise.
In my mental model, I'm trying to minimize the number of avoidable medications that I take, because you never know if they'll have some weird interaction with a truly necessary one. I'm not sure if this is actually the right way to think of it, but it seems to be working out OK so far.
Anecdotes are not useless. They can be inspirational and they can help illuminate possibilities and methods that are otherwise opaque in large-sample statistics. Anecdotes that are consistent with our best scientific understanding are powerful ways of communicating knowledge and providing inspiration for change to those who don't have the ability or inclination to evaluate the studies. In this case, the father is doing several things that large studies tell us are beneficial to health. These unmentioned studies suggest that the father has probably improved his quality of life. Most people I know are far more motivated by such anecdotes than they are by credible statistical analysis.
I disagree with your list of uncontrollable variables. All of them are largely controllable. Much of the medication consumed today is either outright unnecessary or can be reduced with lifestyle changes. You can control the air you breath by controlling where you live and when/where you are most active. You can lower your risk of cancer and many other diseases by lifestyle and environmental changes. The fact that complete control and certainty are impossible is no reason for inaction.
Cancer is literally just a numbers game, people in perfect health at their PEAK get diagnosed with cancer. A top club soccer player is now going through testicular cancer treatment.
I am not sure how general person can control any of this."
I don't disagree that exercise and healthy habits can be great for your health. But the post seemed like it ignored all the other factors.
The fact is, genetics has a much smaller role than what people think it does. If you make good life choices and stay consistent with optimizing your health your genetics won’t have much relevance. Even if your bloodline is prone to cancers or other diseases you can mitigate dying to those conditions if you have awareness to catch problems early.
There is always new research coming out. Some of the research is bogus, just look at earlier days of smoking, the opiate scandal.
We are constantly adding new factors to the mix, like microplastics. The environment is changing.
Of all the things you listed, I think this is controllable.
But I agree genes play a huge role. Warren Buffett and Charlie Munger do no exercise and have famously bad diets, yet both are fully productive and healthy at 91.
Outside of that, it gets very difficult without scanning barcodes, looking up specific items in a database, and periodically doing lab analyses.
There's the "control your food" as in "don't eat fast food" and there's the "control your food" as in "does this fish have high mercury in it?"
What makes you say that? The medications one takes are due in part to decisions made earlier in life, which result in conditions experience later for which the drugs are prescribed.
Also, drugs aren't the only solution to certain medical problems. For example, you can take weight loss pills, or you can actually cut your caloric intake.
This seems like a naive take. While it is technically correct, you most likely cannot significantly influence a number of significant illnesses, such as mental illnesses (e.g. Alzheimers), cancers, blindness, etc. You might slow down the onset at best with some of those.
If one doesn't smoke, drink, and walks at least ±2h a week, what else is there to do that has significant benefits..?
> Also, drugs aren't the only solution to certain medical problems. For example, you can take weight loss pills, or you can actually cut your caloric intake.
Drugs and medical procedures tend to be the only feasible solution to a number of significant illnesses (such as cancer).
I figure if I got just some of those genes, and since I never smoked, not an alcoholic and eat pretty well, I should live to be 150 or so - either that or he will be a pall-bearer at my funeral.
TIL. As a non-native speaker, I've never seen it written and always heard it like "pole bearer", which kinda makes sense: horizontal poles under a coffin.
In linguistics, an eggcorn is an alteration of a phrase through the mishearing or reinterpretation of one or more of its elements,[1] creating a new phrase having a different meaning from the original but which still makes sense and is plausible when used in the same context.
Sorry, that's not how this works. 220 - age is a very crude and not very good guess at the heart rate for a population. It is not YOUR max heart rate, and your max heart rate being higher or lower than that is not a sign of health. It is likely just a sign of your particular heart. It's worth checking in on it every few years and knowing yours.
On the other hand, resting heart rate of under 60 is good. Under 50 is likely better.
Not true in the general case. Asymptomatic bradycardia without increased risk of death may be present in athletes but assuming that's always the case can be dangerous. Other causes include a number of heart diseases, hypothyroidism, sleep apnea, medications such as betablockers...
At which point does that becomes bradycardia and a sign of a health problem? My understanding is that, unless you are an athlete, your resting heart rate won't be that low (as in, < 50)
Couch potatoe and 45? You may have a health problem.
Cardio athlete and 45? Likely means you are in good shape.
My own resting heart rate varies from low 40s when I am in good shape (trained for a marathon) to near 60 when I am not (currently recovering from having a newborn).
I did need an EKG once, and the dr raised an eyebrow at my heart rate, but upon hearing I was a runner he was fine again.
The author's father is apparently blessed with no genetic predisposition for memory/cognitive disorders, degenerative physical disease, etc...
Everybody is different. What works for the author's father may not work for everybody else. Take the above article with a grain of salt.
In the elderly, heart disease and a rapid decline in health after a broken hip are high on the list of events that lead to death. So keeping the cardiovascular system healthy, and strengthening the muscles that support balance and reduce injuries make sense.
Strength training and a sufficient, consistent amount of exertion each week make sense. They do not, of course, guarantee you'll never have a genetic condition, or some other unfortunate incident. That's not how biology and bodies work. But it does help prepare you as you age.
Diet seems much trickier, because dietary needs do vary somewhat depending on your specific body! The hacker approach of experimenting (and journaling) and figuring out what leaves you feeling healthy and energetic is what I'd recommend to anyone who cares!
So write it off as "yet another" anecdote if you please. But also consider whether these ideas are good for your quality of life, and if they are a trade-off worth making.
https://www.bones.nih.gov/health-info/bone/bone-health/exerc...
> and strengthening the muscles that support balance and reduce injuries make sense.
Unclear how stronger muscles prevent broken hips. It's the bone that breaks.
I've read a comment from a nurse that was pretty interesting. She said that people say that 'someone fell and broke a hip'. While in reality it the more common scenario is: 'someone's hip broke, and due to that, they fell'.
I never tried to stay healthy until after I started having health problems (GI issues, mild concussion, etc). I wonder how many other people do the same and how that affects the statistics. Sort of like how "drink a glass of red wine a day" doesn't correlate to health but rather the money to have red wine handy and the circumstances to drink one and only one glass.
You can easily look up what the oldest living populations eat.
Citation needed?
All five were less than 40 years old
All of them showed "somewhat less than 10%" longer lives for the rats and spun that same number in varying ways from "almost no difference" to "considerable lifespan extension" depending, I think, on how much the authors hate rats.
All the studies showed dramatically increased healthspans and much lower decline in rat-performance and quality-of-rat-life thru the rat's lifespan. Or rephrased there wasn't much difference in performance between young exercise rats and young non-exercise rats but a huge difference in performance between old exercise rats and old non-exercise rats. Clearly, if I were a rat, and I dodge traps until I'm old, I'd prefer being an exercise rat. I question how well this study transfers to humans as there's obvious staggering difference in performance between young lazy humans and young "gym rats" (LOL at that pun). I would theorize a bored rat running on a wheel is vastly less motivated than a highly motivated human weight lifter or similar gym user, and that should result in much better QoL for old human "gym-rats". Anecdotal evidence seems to strongly confirm...
The studies all seemed to agree that exercise did not increase maximal lifespan very much if at all.
Depending on which side of the axe you'd prefer to grind, the articles seem to summarize to some variation on "some rats that don't exercise die young" vs "rats on average live about five percent longer if they exercise". Aside from the side issue where some studies report 5% as not much different and others report 5% as a dramatic increase depending, as I stated, on how much the author hates rats. It's literally the same shape graph in all five separate studies, its just selecting the conclusion you'd like to describe that graph.
He was working in the garden daily or going for walks / riding a bike. He had a more active social life than I did before COVID hit. He read daily, did crossword puzzles at night, and ate healthy. No mental or physical issues.
Lifestyle plays a role, but he was dealt good cards genetically as well which I am aware of.
Addicts will fight VERY hard in support of their addiction. Try telling a life long sugar addict to fix their T2 diabetes by eating fewer carbs; they'll completely explode at you. People who die from smoking were usually told about a million times to quit smoking before their diagnosis, LOL.
Innumerate people seem to actively oppose statistics. There is only it works or it doesn't and they'll have a complete meltdown at the concept that maybe 80% of lung cancer is caused by smoking and 20% for other causes therefore there is nothing they can do to alter their pre-determined destiny. Arguably belief in predestination and/or innumeracy could be considered a mental illness (see below) but I'm specifically referencing the stubborn desire to beat the odds by ignoring the odds. (edited to emphasize, the type of thing I'm referring to is the aggressive proselytization of the idea that finding one counterexample or anecdote disproves the entire corpus of all theoretical and applied statistical mathematics)
Most people decline and die younger for some kind of psychological reason. They're depressed so they can't do anything so they can't exercise so they get fat and die of a heart attack, they did in a certain technical sense die because they were fat, but they got fat because they were depressed. Or they have an addiction problem. Or they follow quacks because they think if martyrdom is religiously superior then punishing themselves is superior even if it shortens their life, or they follow medical advice based mostly upon making money off prescriptions, or they follow medical advice that was proven obsolete via research last century, or they are so into collectivism and "fitting in" that they would literally rather die than think for themselves or read a book, whatever the TV (or social media) says is not just good enough, but should be forced on people, even if it kills them.
One thing right now that is available is rapamycin which basically improves health span and lifespan for every animal it is given, won't make you live to 150 but will probably reduce risk of disease.
I am considering starting rapamycin myself as my mom was diagnosed with ALS few months ago (doesn't seem strictly genetic as her mom and dad lived relatively long and didn't get that disease), so I might have some risk genes..
World where people live to 90-100 and where increasing amount have dementia or other age related disease won't be a nice place
Note every animal. Quoting https://link.springer.com/article/10.1007/s11357-020-00274-1:
] Although the overwhelming majority of studies on the effect of rapamycin on longevity in mice have shown a significant increase in lifespan, there are five studies that have reported either no effect or reduced lifespan when treated with rapamycin.
When you write "every animal it is given" .. do you mean only flies and mice?
I've been having a hard time finding results for any other animals.
There's a decade of research with marmosets (here's a 2012 mention about it in Nature - https://www.nature.com/articles/492S18a ), but none of the papers I find report lifespan, only secondary measures (eg, "Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets" - https://onlinelibrary.wiley.com/doi/10.1002/ajp.22927 ).
Since marmosets live for about 15 to 16 years, surely there should be something concrete by now if it has the same effect on middle-aged marmosets when the research started.
I found there's research for dogs, but https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507265/ says it's also ongoing. I haven't found any published results on lifespan only, again, on secondary effects (eg, quoting the paper, "An initial randomized, double-blind veterinary clinical trial confirmed the safety of this treatment and provided indications of potential efficacy (benefits for cardiac function) in dogs".)
What other animals have shown improved lifespan with rapamycin?
If it's only flies and (most) mice, is that really enough to call it "promising" in humans?
There was study on a drug what is now called Everolimus (mTOR inhibitor) and it showed that it increases the influenza vaccine effectiveness on elderly people https://pubmed.ncbi.nlm.nih.gov/25540326/
The dog aging study is ongoing and they are conducting double-blind placebo controlled trial for rapamycin on dogs. https://newsroom.uw.edu/news/tech-entrepreneurs-pledge-25-mi...
Some smaller scale study on rapamycin for dogs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/
I just don't think there is any compound currently that is more promising than rapamycin, so that's why I mentioned it here.
The most promising future treatment seems to do with cellular reprogramming as it increasingly looks like epigenetic alterations are responsible for a large part of aging, the epigenetic drift theory of aging. https://www.nature.com/articles/s41580-019-0204-5
Good video about epigenetic drift theory by Vera Gorbunova from University of Rochester. https://youtu.be/FhfXP_MX0U4?t=639
The current way of doing medicine for the elderly will never work simply because of ageing, it is like trying to bail water from a sinking ship without fixing the hole. Will work for a short while until it doesn't. I am also very skeptical of getting a working treatment for diseases like Alzheimer's disease without intervening in ageing.
Already when I was a teenager I realized that treating ageing is the holy grail of medicine and it seems recently this field is gaining more attention, but realistically it will be decades in minimum until we get some more radical treatments, might be even longer. At least the billionaires have realized that there is not much point being a billionaire if your body is breaking apart.
All we have now is lifestyle choices, possibly some medicine like rapamycin, and just hoping we don't get unlucky. Worrying trend is also people taking HGH for anti-aging but in the lab it seems to have complete opposite effect, it actually seems more like ageing accelerator.
> At age 111, America's oldest veteran is still smoking cigars, drinking whiskey and loving life
> Richard Overton smokes 12 cigars a day, eats grits for breakfast and spends his days on the front porch of his Austin home.
https://www.dallasnews.com/arts-entertainment/2017/06/02/at-...
Not everything his to be a double blind study showing significant effects to be useful.
Unfortunately he didn't keep up, kept complaining about the seat being uncomfortable… what I eventually figured out is, he was riding in boxer shorts >_<
I am not sure how it works for a 80 year old, but if I spend a long time without riding, I'll be uncomfortable too (for a couple of days after the ride too). I don't know exactly what adapts, but it stops after some time.
This sounds like superior genes more so than lifestyle . Some people's bodies give out earlier in life...stuff like heart disease, stoke, cancer, hypertension which may or may not be related to lifestyle.
exercise at 80 if you never did before is not optimal
My two grandfathers never went to the gym yet strong physic and mind. One died in his garden, the other one died while stone cutting. Both 80+, no any supplements whatsoever
