Not actually happened, but we were doing hazard and risk studies for a new mineral processing plant that had some very large gas fired equipment and due to the placement of adjacent units and possibility there could be a turnaround crew on the adjacent unit, the identified scenario was "operator sits on mouse, kills twenty people".
End result is we took the equipment in question out of the normal operator controls and put it in the safety system PLC to remove direct control by fat fingered (butts) of operators.
