Steve Gibson (grc.com) uses assembly for most (all?) of the software he distributes.
For example, his DNS Nameserver Benchmarking utility[1] is 160 KB and when you download it, it's a single uncompressed executable and has a decent win32 UI. It will run any version of Windows going back to Windows 95.
Could you even run a mid-90's era macOS or KDE+Linux executable on a current Mac or Linux machine? (I don't think Gnome even existed yet).
[1]: https://www.grc.com/dns/benchmark.htm