> You don't have to give a Hilton hotel an address like hilton@example.com; it could be bob-2022-05@example.com, right?
Sure, but then it's impossible to remember, or use for classification of incoming mail. Password managers can help with the first problem but not the second one.
I don't understand. You can have filtering rules like "when a new message arrives with 12345@mydomain.com in the To: or Cc:, move mail to lists/foo-list folder".