If you have no power to change anything, you're helpless and it's also hopeless, but for the opposite reason.
In between, there's a balance. Do the best you can to help with what you can. Let the rest go - you can't fix it, so you can't try to carry the responsibility for it.
As a theist, I'm trying to find and maintain the same balance as s1artibartfast. Especially "wisdom to know the difference"...