It's a challenge to recognize those times that your need to work constantly is what you want to do (excited about a technical challenge, avoiding something at home, on an ambition kick), and your boss wouldn't blink an eye if you took the week off rather than work 80 hours.
This hit me when moving from a start-up to a FAANG. There is effectively an infinite amount of work for me to do on any given day, so at some point I just have to decide to stop - if I don't, I'll just end up tired tomorrow with an equally infinite amount of stuff still to do.